Cairo

Throughout its history, the city has fallen victim to the Plague over fifty times.

An excerpt from the article 16 facts about Cairo
The outbreaks of the Black Death took place between 1348 and 1517. The initial one was the most severe and claimed the lives of around 200,000 people. According to Moroccan traveler Ibn Battuta, there were 21,000 deaths a day during the 1348 epidemic.