The people who decided to settle in a town near the river were aware of the benefits of such a location.

Archaeological excavations and computer reconstructions confirm that life in Mohenjo-daro was comfortable and peaceful. The mild climate, fertile soil and location at the crossroads of trade routes contributed to the rapid development and prosperity of the city. The locals worked in agriculture, grew wheat, barley, sesame, dates, and cotton. The rich harvest and favorable location allowed the inhabitants to exchange their goods for various other raw materials, such as metal, precious stones, and spices from Central Asia, Afghanistan, Persia, and South India. Everything was going great, up to a point - something unexpectedly catastrophic happened.

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Read the entire article 26 about Mohenjo-daro, from which this fragment is taken.