Nettle has analgesic properties. In folk medicine, nettle leaves were used to relieve pain. Its pain-relieving properties have been scientifically proven.

Researchers at the University of Plymouth studied a group of 18 people suffering from joint and bone inflammation, disc pain, and pain caused by injuries such as sprains and tendinopathy, including "tennis elbow". The studies conducted showed the analgesic effect of nettle with no serious side effects other than a transient rash.