The disease causes several symptoms from the body’s functioning.

• Loss of body fat and muscle, resulting in emaciation and cachexia
• Lowering of body temperature below 36 degrees Celsius
• Reduction in blood pressure below 120/70 mm Hg
• Bruising of the distal parts of the limbs and edema
• Abnormal heart rhythm
• A feeling of fullness in the abdomen combined with bloating and constipation
• Disappearance of menstruation
• Change in the size of the uterus and ovaries
• The appearance of a characteristic fuzz on the skin all over the body, known as lanugo
• Hair loss
• Osteopenia with osteoporosis
• Inflammation of the stomach and intestines
• Dehydration
• Gingivitis, caries
• Intolerance to cold, fatigue, insomnia, yellow skin