Palermo

Founded by the Phoenicians over 2700 years ago, the Port of Palermo is, along with the port of Messina, the main port of Sicily.

An excerpt from the article 21 facts about Palermo

From here, ferries connect Palermo with Cagliari, Genoa, Livorno, Naples, Tunis, and other cities and carry a total of almost two million passengers a year. It is also an important port for cruise ships.