At the orphanage's music school, Vivaldi taught girls to play the violin but also began composing his first debut works.

In 1705, his first collection of sonatas a tre (a trio sonata, a sonata for two solo instruments and basso continuo) was published, followed four years later by a new series of violin sonatas. In 1711, he created his series of concertos entitled "L'Estro Armonico." He continued to create for the Ospedale della Pieta until the end of his life.