Emptiness means the absence of a phenomenon's nature. Phenomena that have no essence of their manifest because they are dependent on many factors. They exist in a dependent way and have no real existence. This impermanence also applies to living beings, which also lack their substance (soul).
According to Buddhism, human beings are composed of five clusters, which disintegrate at the death of the physical body. In addition to these five clusters, there is the mind ("pure consciousness"), which is the only one that does not annihilate.