Philadelphia

In 1793, the largest yellow fever epidemic in the history of the United States broke out in Philadelphia.

An excerpt from the article 22 facts about Philadelphia

In the period from August 1 to November 9, the plague killed at least 4000 to 5000 people there, which constituted about 10 percent of the city's population at that time. During this time, 20.000 people left the city, including congressional and executive branch officials of the federal government. Some neighboring cities did not admit refugees from Philadelphia, and major port cities, including Baltimore and New York, quarantined refugees and goods from Philadelphia.