In the years 540-480 BC, a pre-Socratic Greek philosopher (the period in ancient philosophy before Socrates) lived in Ephesus - Heraclitus.

An excerpt from the article 30 facts about Epheseus

The most famous element of the philosophy of Heraclitus of Ephesus is the concept of change as the central element of the world (ta panta rhei - everything flows), as Heraclitus put it in the famous phrase "It is impossible to step into the same river twice."