Jamestown

Soon after the arrival of the British, they engaged in a crossfire with the local Indian tribe, the Powhatan.

An excerpt from the article 32 facts about Jamestown
The Powhatan Indians inhabited eastern Virginia. During the British colonization of 1607, there were approximately 14,000-21,000 Powhatans living in the region surrounding Jamestown, the Tsenacommacah.

The construction of fortifications was not yet completed, so the settlers used naval gunfire from the ships docked nearby. That prevented Jamestown from being overwhelmed by hundreds of Natives storming the settlement.