It was volcanically active during the Pleistocene and Holocene, producing mainly lava flows. The last eruption took place around 750 AD. In 1993, steam emissions were observed from the volcano, which could represent another eruption.
Chile's geological agency, SERNAGEOMIN, ranks Ojos del Salado 75th (out of 92) as a volcano with a very low risk of eruption. Future eruptions would likely produce lava domes, lava flows and minor explosive activity. Impacts would likely be limited to the immediate vicinity of the volcano, such as the Chile Route 31 highway.